RESUMO
Tanto o exame dos textos winnicottianos quanto o estudo das últimas elaborações doensino de Lacan oferecem contribuições para o manejo de casos e situações difíceis. Apesar dediferenças fundamentais, as abordagens desenvolvidas por estes dois autores têm em comum asnoções de processo, gradação e continuidade. Tais premissas são adotadas como essenciais paraa superação dos limites impostos pela técnica analítica clássica e, consequentemente, para inclusãode casos refratários ao tratamento erigido como padrão pelas neuroses.
Both the examination of Winnicotts texts and the study of the last elaborations of Lacansteachings, have significant contributions to offer regarding the handling of especially difficult casesand situations. In spite of their fundamental differences, both authors share the notions of process,gradation and continuity in their approach. These assumptions are established as critical to overcomingthe limits imposed by the classical analytical technique and, consequently, to including patientswho do not fit in the standard treatment of neurotic illnesses.
Assuntos
Humanos , Psicanálise/métodos , PsicanáliseRESUMO
Growth hormone (GH) excess causes an increment in the metabolic rate and in reactive oxygen species generation, which accelerate the ageing process in mammals. Considering that there is no information on this subject in fish, the aim of the present study was to evaluate the excess GH effect on senescence in a zebrafish (Danio rerio) transgenic model. In order to reach this objective, we analyzed the phenotype of spinal curvature and expression of genes related to the anti-oxidant defense system and myogenesis in muscle of 8 and 30 months old GH-transgenic males. Gene expression analyses revealed that both superoxide dismutase isoforms were down-regulated only in 30 months old animals, while glutamate cysteine ligase was down-regulated in GH-transgenic zebrafish. Acceleration of the spinal curvature and a reduction in the expression of miogenin at both ages and MyoD in the old fish were also observed. Although neurolipofuscin accumulation was not significant in GH-transgenic zebrafish, the estimation of maximum longevity based on the von Bertalanffy growth function was significantly lower in this group. The results obtained here indicate that GH overexpression reduces the transcription of anti-oxidant defense system and myogenesis-related genes, which probably accelerates senescence in the zebrafish transgenic model used.
Assuntos
Glutamato-Cisteína Ligase/genética , Hormônio do Crescimento/metabolismo , Desenvolvimento Muscular/genética , Curvaturas da Coluna Vertebral/metabolismo , Superóxido Dismutase/genética , Peixe-Zebra/metabolismo , Envelhecimento/fisiologia , Animais , Animais Geneticamente Modificados/genética , Animais Geneticamente Modificados/metabolismo , Antioxidantes/metabolismo , Carpas/genética , Amplificação de Genes , Regulação da Expressão Gênica no Desenvolvimento , Glutationa/genética , Glutationa/metabolismo , Gráficos de Crescimento , Hormônio do Crescimento/genética , Hormônio do Crescimento/fisiologia , Peroxidação de Lipídeos/genética , Lipofuscina , Masculino , Músculo Esquelético/metabolismo , Fenótipo , Reação em Cadeia da Polimerase , Isoformas de Proteínas/genética , Isoformas de Proteínas/metabolismo , RNA Mensageiro/metabolismo , Radiografia , Curvaturas da Coluna Vertebral/diagnóstico por imagem , Peixe-Zebra/genéticaRESUMO
The idea that moves this debate is to look at these two authors, both of great influence on our way of thinking psychoanalysis today, with a view to their respective contributions and their effects on what we do daily in our practices(AU)
